Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27826
Title: Expression, regulation and functional characterization of the proline rich acidic protein
Authors: ZHANG JINQIU
Keywords: Liver carcinoma, Colorectal carcinoma, Gene regulation, Splice variants, mutation, differentiation
Issue Date: 26-Oct-2004
Source: ZHANG JINQIU (2004-10-26). Expression, regulation and functional characterization of the proline rich acidic protein. ScholarBank@NUS Repository.
Abstract: We describe the isolation, distribution and functional characterization of the rat and human proline rich acidic protein gene (PRAP). PRAP was abundantly expressed in the epithelial cells of human liver, kidney, gastrointestinal tract and cervix. PRAP expression was tightly associated with sodium butyrate induced differentiation and was significantly down-regulated in hepatocellular carcinoma, gastric carcinoma and right colon adenocarcinoma compared to the matched normal tissues. The suppression of PRAP expression in tumor cells was due to epigenetic mechanisms involving histone deacetylation and methylation. PRAP and its variants showed cell growth inhibition functions in cell lines. Loss of function mutations were detected in the tumor tissues of liver and colon. The data suggest that PRAP and its variants play an important role in maintaining normal growth homeostasis in epithelial cells. The suppression and mutation of PRAP in cancers may cause growth dysregulation, a hallmark of the carcinogenic process.
URI: http://scholarbank.nus.edu.sg/handle/10635/27826
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