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Title: Design and development of a bioreactor for the in-vitro engineering of soft tissues
Keywords: bioreactor, human dermal fibroblasts, cyclic straining, tensile testing, alignment and orientation, collagen fibres
Issue Date: 19-May-2004
Citation: KWAN MENG SANG (2004-05-19). Design and development of a bioreactor for the in-vitro engineering of soft tissues. ScholarBank@NUS Repository.
Abstract: Interaction with the mechanical environment is believed to be necessary both in vivo and in vitro for the adaptation and maintenance of cells to exhibit the correct mechanical characteristic and thus indirectly maintain the correct function balance of tissues. In order to study the effect of strain and strain rate, an in-vitro straining device had been developed according to a set of design criteria, to apply a cyclic tensile strain on cell seeded knitted PLGA scaffold. The biocompatibility of the system and the effect of the designed mechanical stimulus were assessed. The ultimate goal for this field of study is to obtain the optimal straining parameters for future in vitro culturing of neo tissues with comparable strength to that of the original tissue. A standalone microprocessor controller allows all displacement parameters to be easily modified.
Appears in Collections:Master's Theses (Restricted)

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