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Title: Possible role of diva in microglial dual effects and the stem cell differentiation
Authors: LI LV
Keywords: Microglia, Neuron, Neural stem cell, cytotoxicity, neuroprotection, Bcl-2 family
Issue Date: 11-Apr-2008
Citation: LI LV (2008-04-11). Possible role of diva in microglial dual effects and the stem cell differentiation. ScholarBank@NUS Repository.
Abstract: Opposing functions of activated microglia, namely neuroprotection/neurotrophy versus neurodestruction/neurotoxicity, have been confirmed to be configured by equilibrium among various microglial factors released into microenvironment. Under microglial neuroprotective function, Diva, a Bcl-2 family member, was increased and translocated from cytosol onto mitochondria. Overexpression of Diva in neural cells resulted in an increase in proliferation and decrease in cell death. Double labelling showed Diva was expressed in neurons and neural stem cells. A down-regulation of Diva after neural stem cell differentiation has indicated that Diva could arrest neural stem cells in G0/G1 phase and prevent stem cells from escaping of cell cycle. Therefore, Diva may play an important role in cell differentiation and prevention of cells from death. To manipulate ability of neural stem cells against microglial cytotoxicity and differentiation of neural stem cells may be helpful in cell therapeutic strategies to treat neurological diseases and CNS injuries.
Appears in Collections:Ph.D Theses (Open)

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