Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27807
Title: Characterisation of CD137 as a neoantigen on cancer cells
Authors: THUM HUEI YEE, ELAINE
Keywords: CD137, cancer, neoantigen
Issue Date: 27-Mar-2008
Source: THUM HUEI YEE, ELAINE (2008-03-27). Characterisation of CD137 as a neoantigen on cancer cells. ScholarBank@NUS Repository.
Abstract: CD137 is a co-stimulatory receptor found on activated T lymphocytes and certain cancer cells. In particular, CD137 was detected on B cells in 14 out of 14 cases of chronic lymphocytic leukaemia analysed, but not in healthy B cell samples. Thus, this study aims to characterize the potential role of CD137 as a cancer neoantigen. Using cell lines which overexpress CD137, it was found that CD137 does not protect cancer cells against cell death mediated by lymphokine activated killer cells and chemotherapeutic drugs. Also, CD137-expressing cells do not enhance monocyte adhesion, a process which may increase the number of tumour associated macrophages. These in vitro data suggest that CD137 expression does not confer a survival advantage upon cancer cells. Finally, to understand how soluble CD137 might disrupt CD137-mediated signaling, this study also aims to determine if soluble CD137 associates with membrane-bound CD137. Our results, however, suggest that this is unlikely to be the case.
URI: http://scholarbank.nus.edu.sg/handle/10635/27807
Appears in Collections:Master's Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Elaine_Thum_ thesis v2.pdf717.43 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

260
checked on Dec 11, 2017

Download(s)

261
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.