Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27800
Title: Studies of chondroitin sulfate on palatal fibroblasts : Implication for wound healing
Authors: ZOU XIAOHUI
Keywords: cell adhesion, cell migration, cell proliferation, chondroitin sulfate, palatal fibroblast, wound healing
Issue Date: 21-Aug-2006
Source: ZOU XIAOHUI (2006-08-21). Studies of chondroitin sulfate on palatal fibroblasts : Implication for wound healing. ScholarBank@NUS Repository.
Abstract: An important phase of early wound healing involves secretion of glycosaminoglycans (GAGs) by fibroblasts which form a hydrophilic matrix suitable for remodeling during healing. In this thesis a series of studies on chondroitin sulfate (CS) were carried out and presented. It was found that CS involved in palatal wound healing in in-vivo and in-vitro models; depletion of CS sulfation with / without the addition of exogenous CS affected palatal fibrobalstsa?? adhesion, proliferation and migration; and also the result showed that different sulfation pattern of CS can improve some of palatal fibroblast activities. And then RNA-mediated interference was used to block chondroitin synthesis and resulted in the inhibition of cell adhesion, proliferation, migration and cytokinesis defects in palatal fibroblast. These findings provide the biological bases for further studies on the structure/function of CS and their application on clinical palatal wound healing.
URI: http://scholarbank.nus.edu.sg/handle/10635/27800
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Zou Xiao Hui - PhD thesis.pdf2.93 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

250
checked on Dec 11, 2017

Download(s)

371
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.