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Title: Studies of chondroitin sulfate on palatal fibroblasts : Implication for wound healing
Keywords: cell adhesion, cell migration, cell proliferation, chondroitin sulfate, palatal fibroblast, wound healing
Issue Date: 21-Aug-2006
Citation: ZOU XIAOHUI (2006-08-21). Studies of chondroitin sulfate on palatal fibroblasts : Implication for wound healing. ScholarBank@NUS Repository.
Abstract: An important phase of early wound healing involves secretion of glycosaminoglycans (GAGs) by fibroblasts which form a hydrophilic matrix suitable for remodeling during healing. In this thesis a series of studies on chondroitin sulfate (CS) were carried out and presented. It was found that CS involved in palatal wound healing in in-vivo and in-vitro models; depletion of CS sulfation with / without the addition of exogenous CS affected palatal fibrobalstsa?? adhesion, proliferation and migration; and also the result showed that different sulfation pattern of CS can improve some of palatal fibroblast activities. And then RNA-mediated interference was used to block chondroitin synthesis and resulted in the inhibition of cell adhesion, proliferation, migration and cytokinesis defects in palatal fibroblast. These findings provide the biological bases for further studies on the structure/function of CS and their application on clinical palatal wound healing.
Appears in Collections:Ph.D Theses (Open)

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