Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27781
Title: [188Re(CO)3]-chelates as therapeutic radiopharmaceuticals: Targeting hepatocellular carcinoma
Authors: MAUNG MAUNG SAW
Keywords: Hepatocellular carcinoma, internal radiation therapy, [188Re(CO)3]-chelates, Lipiodol surrogates, biodistribution,
Issue Date: 3-Mar-2006
Source: MAUNG MAUNG SAW (2006-03-03). [188Re(CO)3]-chelates as therapeutic radiopharmaceuticals: Targeting hepatocellular carcinoma. ScholarBank@NUS Repository.
Abstract: Internal radiation therapy (IRT) has been used in the management of hepatocellular carcinoma. The radiographic contrast medium, Lipiodol, when injected through the hepatic artery, accumulates in liver cancer cells. Octadecane could be regarded as a Lipiodol-mimic bioactive molecule. Different bidentate and tridentate ligands containing a long chain hydrocarbon in a side chain were synthesized as Lipiodol surrogates and coordinated to fac-[M(CO)3]+ core (M = 99mTc, 186Re or 188Re) and then dissolved in Lipiodol. As a variation, a new a??[2+1B] mixed-ligand approacha?? was used to synthesize [Re(CO)3(2+1B)] complexes. The natural product Lipiodol was derivatized with monodentate and polydentate ligands and their complexation to [Re(CO)3] was proven by ESI/MS studies. A Lipiodol mimic was synthesized and characterized. Biodistribution of fac-[188Re(OH2)3(CO)3]+ and three selected [99mTc(CO)3] complexes of Lipiodol surrogates had been studied. The complexes are mainly localized in the liver for at least 6 h and their distribution patterns are comparable to those of reported Re-Lipiodol complexes.
URI: http://scholarbank.nus.edu.sg/handle/10635/27781
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