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Title: Development of chiral stationary phases for HPLC based on selectively modified cyclodextrins
Keywords: Cyclodextrins, selective-modification, chiral stationary phases, HPLC, enantioseparation, optimization
Issue Date: 15-Dec-2004
Citation: LAI XIANGHUA (2004-12-15). Development of chiral stationary phases for HPLC based on selectively modified cyclodextrins. ScholarBank@NUS Repository.
Abstract: The key aim of this project focuses on design of novel chiral stationary phases (CSPs) based on cyclodextrins (CDs) and development of processes for enantioseparation of racemic drugs as well as other racemic compounds by HPLC. Several series of CD-based chiral selectors with chemically well-defined structure were facilely prepared. Durable CSPs with good chiral separation abilities were successfully afforded after immobilizing the resultant chiral selectors onto the surface of silica gel via hydrosilylation or the Staudinger reaction. Consequently, this work investigated the influences of CD types, spacer-arm length, per-functionalizing reagents as well as different immobilization procedures on the enantioseparation properties of these CD-based CSPs; conditions-optimization was carried out based on CSP Me-3-b-CD. Part of possible enantioseparation mechanism was elucidated.
Appears in Collections:Ph.D Theses (Restricted)

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