Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27743
Title: Intestine of Zebrafish: Regionalization, Characterization and Stem Cells
Authors: WANG ZHENGYUAN
Keywords: zebrafish,intestine,regionalization,ridge,transcriptome,GSEA
Issue Date: 13-Aug-2010
Source: WANG ZHENGYUAN (2010-08-13). Intestine of Zebrafish: Regionalization, Characterization and Stem Cells. ScholarBank@NUS Repository.
Abstract: Unlike the mammalian digestive tract that has been developed into distinct regions for different functions, fish have a relatively simple intestine and many fishes have no recognizable stomach. We used the zebrafish microarray approach to characterize its intestine. By dividing the zebrafish intestine into seven segments along its length, we found that the first five segments resemble the mammalian small intestine and the last two segments resemble the mammalian large intestine. We then investigated the role of Notch signaling and found that a specific group of glycogen-rich fibroblasts were involved in the Notch-mediated cell fate decision process. Further, we studied the effects of radiation and found an interesting pattern of regeneration in the intestine. Moreover, the number of intestinal stem cells was investigated through a novel computational model, which was applicable not only to zebrafish, but also to mammalian intestinal tracts.
URI: http://scholarbank.nus.edu.sg/handle/10635/27743
Appears in Collections:Ph.D Theses (Open)

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