Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27715
Title: Experimental and clinical evaluation of tissue engineered bone grafts for calvarial reconstrution
Authors: JAN-THORSTEN SCHANTZ
Keywords: Calvarial Reconstruction, Tissue Engineering, Bone, Mesenchymal Progenitor Cells, Osteoblasts, Biodegradable Scaffolds
Issue Date: 21-Jul-2004
Source: JAN-THORSTEN SCHANTZ (2004-07-21). Experimental and clinical evaluation of tissue engineered bone grafts for calvarial reconstrution. ScholarBank@NUS Repository.
Abstract: Repair of calvarial defects remains a challenge for reconstructive surgery. The paucity of techniques and materials emphasize the need for alternative bone formation strategies. The objective for this Ph.D. Thesis was therefore firstly: to develop a novel concept for calvarial reconstruction by tissue engineering using a fully biodegradable polymer-hydrogel system in combination with two mesenchymal cells and secondly: to evaluate in vitro and in vivo the feasibility of stem cells for bone formation. The results indicated that the PCL-hydrogel system represents a suitable physiologic model for tissue regeneration in vitro. Preclinical and clinical studies indicated that immediate structural and functional reconstruction was achieved and that bone formation occurred after 3 month. Secondly it was observed that the environment acts as an external developmental control for cell differentiation.In this work a novel concept for calvarial reconstruction was developed and investigated in preclinical and clinical studies. Furthermore insights in stem cell differentiation mechanisms were obtained.
URI: http://scholarbank.nus.edu.sg/handle/10635/27715
Appears in Collections:Ph.D Theses (Open)

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Cover Page_Preface_TOC 29May.pdf111.39 kBAdobe PDF

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C1 Introduction_29May.pdf130.52 kBAdobe PDF

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C2 Literature Review_29May.pdf413.24 kBAdobe PDF

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C3 Proposed Research Prog_29May.pdf237.54 kBAdobe PDF

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C4 Cell Culture Studies_29May.pdf1.77 MBAdobe PDF

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C5 Rabbit Model_29May.pdf1.14 MBAdobe PDF

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C6 Clinical Study_29May.pdf904.22 kBAdobe PDF

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C7 Conclusion_29May.pdf30.75 kBAdobe PDF

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References_29May.pdf127.56 kBAdobe PDF

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Appendix_29May.pdf177.01 kBAdobe PDF

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