Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27713
Title: Tissue engineering approaches to tendon repair: Studies on the use of bone marrow stromal cells and knitted Poly (D, L-Lactide-co-Glycolide scaffold)
Authors: OUYANG HONGWEI
Keywords: Tissue engineering, tendon repair, bone marrow stromal cell,knitted scaffold,PLGA, rabbit model
Issue Date: 28-Oct-2003
Source: OUYANG HONGWEI (2003-10-28). Tissue engineering approaches to tendon repair: Studies on the use of bone marrow stromal cells and knitted Poly (D, L-Lactide-co-Glycolide scaffold). ScholarBank@NUS Repository.
Abstract: This present study aimed to investigate the feasibility and efficacy of the tissue engineering graft, i.e. bone marrow stromal cells (bMSCs) seeded knitted Poly (D,L-lactide-co-glycolide ) (PLGA) scaffold, for tendon repair. Five sequential stages of experiment were carried out in rabbit model to investigate the potential of the bMSCs isolated in this study, the fate of the bMSCs after implantation, the favorite material for bMSCs delivery, the efficacy of bMSCs-scaffold composite for tendon repair and the effect of bMSCs on the tendon to bone insertion healing. The results showed that the bMSCs used in this study were multipotential, the implanted allogeneic bMSCs could survive as long as 8 weeks and were able to differentiate into spindle-shape cells after implantation, bMSCs were more likely to adhere to and grow on PLGA as compare to other seven synthetic biodegradable polymers, bMSCs seeded knitted PLGA scaffold could improve the structure and biomechanics of tendon repair, and the bMSCs exhibited the potential to restore the native structure at the tendon to bone interface healing. In summary, these results illustrated that the tissue engineering graft composed of bMSCs and knitted PLGA are promising substitute for tendon repair.
URI: http://scholarbank.nus.edu.sg/handle/10635/27713
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