Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27708
Title: Development and degradation studies of bioactive polycaprolactone scaffolds for bone tissue engineering
Authors: LAM XU FU, CHRISTOPHER
Keywords: Bioresorbable scaffolds, poly(e-caprolactone), tricalcium phosphate
Issue Date: 9-Jun-2004
Source: LAM XU FU, CHRISTOPHER (2004-06-09). Development and degradation studies of bioactive polycaprolactone scaffolds for bone tissue engineering. ScholarBank@NUS Repository.
Abstract: Bioresorbable 3D poly(e-caprolactone) (PCL) scaffolds with a fully interconnected pore network fabricated via the Fused Deposition Modeling (FDM) has previously been reported. The continued development of these scaffolds involved the enhancement of mechanical properties and bioactivity through the incorporation of a bioceramic, b-tricalcium phosphate (b-TCP) as filler material to form an evolved second-generation biocomposite scaffold. The integration of b-TCP was also hypothesized to increase its degradation rate. PCL-TCP(20%wt.) scaffolds were successfully fabricated. As PCL has a slow degradation rate of up to 4 years, the in-vitro studies involved an accelerated and a long-term hydrolytic degradation using sodium hydroxide and saline, respectively. An in-vivo degradation study, in a rabbit model for 6-months was also conducted. The degraded scaffolds were evaluated for their physical and chemical properties. From the results thus far, the PCL-based scaffolds presented a surface erosion phenomenon. The in-vivo study further verified the biocompatibility of PCL and PCL-TCP scaffolds.
URI: http://scholarbank.nus.edu.sg/handle/10635/27708
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