Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27691
Title: Clinical pharmacokinetics of tacrolimus in Asian liver transplant patients
Authors: SAM WAI JOHNN
Keywords: Population pharmacokinetics, tacrolimus, asian, liver transplant, nonmem, FK506
Issue Date: 18-Dec-2004
Source: SAM WAI JOHNN (2004-12-18). Clinical pharmacokinetics of tacrolimus in Asian liver transplant patients. ScholarBank@NUS Repository.
Abstract: The general aim of the thesis is to investigate the population pharmacokinetics (PK) of tacrolimus (Tac) (FK506) in the local Asian liver transplant recipients so as to identify possible relationships between clinical covariates and population parameter estimates using the NONMEM program. This can be achieved by (A) determining the population PK of Tac in the local Asian paediatric liver transplant recipients, which represents a special subpopulation with special PK characteristics, and (B) determining the population PK of Tac in the local Asian adult and paediatric liver transplant recipients. The population models that were constructed have identified significant relationships in Asian liver transplant patients between the PK of Tac and arthropometric characteristics of the patients, as well as the clinical conditions of the patients. Using these models, in conjunction with Bayesian forecasting, a truly individualized immunosuppressive therapy of Tac can be developed and applied.
URI: http://scholarbank.nus.edu.sg/handle/10635/27691
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
SamWJ.pdf2.61 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

225
checked on Dec 11, 2017

Download(s)

329
checked on Dec 11, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.