Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27685
Title: Sample size, error rates and effects of prior-misspecifications in phase II clinical trials
Authors: LONG YU
Keywords: Phase II clinical trials, sample size, error rates, misspecifications, prior distribution, posterior distribution.
Issue Date: 6-Oct-2004
Source: LONG YU (2004-10-06). Sample size, error rates and effects of prior-misspecifications in phase II clinical trials. ScholarBank@NUS Repository.
Abstract: In the last decades, there have been important developments in statistical designs in phase II clinical trials. Those designs either optimize the expected sample size or the total number of sample size, under the constraints of some system error rates. This thesis briefly discusses the relationship among the error rates and provides comparisons among the optimal designs under different error rates. Moreover, this thesis discusses the effects of prior-misspecifications. Two designs are considered, Bayesian sequential design and sequential Bayesian decision theoretic design. Our findings are, Bayesian sequential designs are robust to misspecifications of prior variances and they are robust to the misspecifications of prior means if the prior variances are large or true prior means are large; the sequential Bayesian decision theoretic designs are robust to the misspecifications of prior means and misspecifications of prior variances, if the true prior means or the true prior variances are large respectively.
URI: http://scholarbank.nus.edu.sg/handle/10635/27685
Appears in Collections:Master's Theses (Open)

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