Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27672
Title: Topical aspirin gel formulation and assessment of its irritancy in an in vivo model
Authors: MA SHWE ZIN NYUNT
Keywords: aspirin; topical gels; copolymer of N-vinylacetamide and sodium acrylate (PNVA); skin irritation; permeation; bioadhesion
Issue Date: 18-Oct-2004
Source: MA SHWE ZIN NYUNT (2004-10-18). Topical aspirin gel formulation and assessment of its irritancy in an in vivo model. ScholarBank@NUS Repository.
Abstract: Non-aqueous aspirin plasters consisting of copolymer of N-vinylacetamide and sodium acrylate (PNVA) cross-linked with aluminum chloride (AlCl3) in mixture of propylene glycol (PG) and N-methyl-2-pyrrolidone (NMP) and glycerin were prepared. The viscoelastic and bioadhesive properties of the plaster, drug release and permeation through pig and human skins and irritancy of the plasters on pigs were studied. The stability of aspirin in the plaster was also investigated. The formulation variables were screened and optimized. The drug release and permeation decreased with increasing PNVA, AlCl3 and PG amounts. Skin irritation increased with increasing aspirin concentration and duration of application. The results showed that the formulation with PNVA concentration of 9%, ratios of PNVA to AlCl3 at 1.5:1 and PG to NMP at 2:1 is the most suitable topical aspirin preparation for treatment of localized itch and pain.
URI: http://scholarbank.nus.edu.sg/handle/10635/27672
Appears in Collections:Master's Theses (Open)

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