Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/27660
Title: Stimuli sensitive core-shell nanoparticles for targetted drug delivery
Authors: CHOOI KAR WAI
Keywords: Poly(N-isopropylacrylamide); Core-shell nanoparticles; Thermally-responsive; pH-responsive; Cyclosporin A; Indomethacin
Issue Date: 10-Dec-2003
Source: CHOOI KAR WAI (2003-12-10). Stimuli sensitive core-shell nanoparticles for targetted drug delivery. ScholarBank@NUS Repository.
Abstract: A new type of stimuli-sensitive core-shell nanoparticles based on thermally responsive cholesteryl end-capped poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) [P(NIPAAm-co-DMAAm)], and thermally pH responsive poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide-co-oleic acid) [P(NIPAAm-co-DMAAm-co-OA)] amphiphilic polymers were synthesised and utilised to encapsulate cyclosporin A (CyA) and indomethacin (IMC) by a membrane dialysis method. The core-shell nanoparticles were spherical, and had a mean diameter less than 200 nm. They demonstrated reversibility of thermoresponsive aggregation/dispersion and deformation/reformation of structure in heating and cooling thermal cycles through the lower critical solution temperature (LCST). The LCST of nanoparticles was studied in various media. The stability of nanoparticles was examined in the presence of serum proteins and salts. Both the nanoparticles systems provided great loading capacity for CyA and/or IMC. Various factors that influence drug encapsulation efficiency were investigated. Release of both CyA and IMC was dependent on temperature, pH and actual drug loading. The nanoparticles developed would make a good carrier for targeted drug delivery.
URI: http://scholarbank.nus.edu.sg/handle/10635/27660
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