Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbcan.2010.01.002
Title: Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy
Authors: Li, F. 
Sethi, G. 
Keywords: Apoptosis
Cancer
Chemoresistance
NF-κB
Radioresistance
Issue Date: 2010
Source: Li, F.,Sethi, G. (2010). Targeting transcription factor NF-κB to overcome chemoresistance and radioresistance in cancer therapy. Biochimica et Biophysica Acta - Reviews on Cancer 1805 (2) : 167-180. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbcan.2010.01.002
Abstract: Activation of transcription factor NF-κB is frequently encountered in tumor cells and contributes to aggressive tumor growth and resistance to chemotherapy and ionizing radiation during cancer treatment. Accumulating evidence over the last few years indicate that most chemotherapeutic agents and radiation therapy activate NF-κB in vitro and in vivo. Moreover, induction of chemoresistance and radioresistance is mediated through several genes regulated by NF-κB and inhibition of this transcription factor increases sensitivity of cancer cells to the apoptotic action of chemotherapeutic agents and to radiation exposure. This review explores the role of NF-κB and its regulated genes in resistance of tumor cells to chemotherapeutic agents and radiation and evaluates the importance of targeting NF-κB as a potential therapeutic approach to overcome chemoresistance and radioresistance for cancer treatment. © 2009 Elsevier B.V. All rights reserved.
Source Title: Biochimica et Biophysica Acta - Reviews on Cancer
URI: http://scholarbank.nus.edu.sg/handle/10635/27433
ISSN: 0304419X
DOI: 10.1016/j.bbcan.2010.01.002
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