Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neuint.2007.05.016
Title: Hydrogen sulfide: Neurochemistry and neurobiology
Authors: Qu, K.
Lee, S.W. 
Bian, J.S. 
Low, C.-M. 
Wong, P.T.-H. 
Keywords: CNS
Cystathionine β-synthase
Hydrogen sulfide
Neuromodulator
Stroke
Issue Date: 2008
Source: Qu, K., Lee, S.W., Bian, J.S., Low, C.-M., Wong, P.T.-H. (2008). Hydrogen sulfide: Neurochemistry and neurobiology. Neurochemistry International 52 (1) : 155-165. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neuint.2007.05.016
Abstract: Current evidence suggests that hydrogen sulfide (H2S) plays an important role in brain functions, probably acting as a neuromodulator as well as an intracellular messenger. In the mammalian CNS, H2S is formed from the amino acid cysteine by the action of cystathionine β-synthase (CBS) with serine (Ser) as the by-product. As CBS is a calcium and calmodulin dependent enzyme, the biosynthesis of H2S should be acutely controlled by the intracellular concentration of calcium. In addition, it is also regulated by S-adenosylmethionine which acts as an allosteric activator of CBS. H2S, as a sulfhydryl compound, has similar reducing properties as glutathione. In neurons, H2S stimulates the production of cAMP probably by direct activation of adenylyl cyclase and thus activate cAMP-dependent processes. In astrocytes, H2S increases intracellular calcium to an extent capable of inducing and propagating a "calcium wave", which is a form of calcium signaling among these cells. Possible physiological functions of H2S include potentiating long-term potentials through activation of the NMDA receptors, regulating the redox status, maintaining the excitatory/inhibitory balance in neurotransmission, and inhibiting oxidative damage through scavenging free radicals and reactive species. H2S is also involved in CNS pathologies such as stroke and Alzheimer's disease. In stroke, H2S appears to act as a mediator of ischemic injuries and thus inhibition of its production has been suggested to be a potential treatment approach in stroke therapy. © 2007 Elsevier Ltd. All rights reserved.
Source Title: Neurochemistry International
URI: http://scholarbank.nus.edu.sg/handle/10635/27327
ISSN: 01970186
DOI: 10.1016/j.neuint.2007.05.016
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

180
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

164
checked on Nov 29, 2017

Page view(s)

192
checked on Dec 11, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.