Please use this identifier to cite or link to this item:
|Title:||All in the timing: A comparison between the cardioprotection induced by H2S preconditioning and post-infarction treatment|
|Citation:||Pan, T.-T., Chen, Y.Q., Bian, J.-S. (2009). All in the timing: A comparison between the cardioprotection induced by H2S preconditioning and post-infarction treatment. European Journal of Pharmacology 616 (1-3) : 160-165. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejphar.2009.05.023|
|Abstract:||In the current study, we investigated the delayed cardioprotection induced by H2S preconditioning in an in vivo rat model of myocardial infarction. Assessment of infarct size revealed that a single bolus of NaHS (a donor of H2S, at 0.1-10 μmol/kg body weight) administered 1 day before myocardial infarction produced a strong infarct-limiting effect. A time course study demonstrated that the protection lasted at least 3 days after the preconditioning stimulus. We further compared the effect of H2S preconditioning with post-infarction treatment. Although injection of NaHS (1 μmol/kg once daily) for 3 days after myocardial infarction also significantly decreased infarct size, the protective effect was significantly lower than that afforded by H2S preconditioning. A combination of both preconditioning and post-treatment did not produce a stronger protection compared with H2S preconditioning alone. Pretreatment with chelerythrine chloride (5 mg/kg, i.p.), a protein kinase C (PKC) inhibitor, 15 min before NaHS administration blocked the infarct-sparing effect of H2S preconditioning. In conclusion, the current study provided the first evidence that H2S preconditioning produces strong late cardioprotection through a PKC-dependent mechanism. Such protection could not be reproduced by H2S treatment after the infarction occurred. A combination of both preconditioning and post-treatment does not provide additional benefit and hence is not necessary when the access to preconditioning has been secured. © 2009 Elsevier B.V.|
|Source Title:||European Journal of Pharmacology|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Nov 19, 2018
WEB OF SCIENCETM
checked on Nov 19, 2018
checked on Nov 17, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.