Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jchromb.2008.12.067
Title: A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma
Authors: Wang, M. 
Zhou, J. 
Casey, P. 
Khoo, Y.M.
Lee, H.S. 
Keywords: Cysmethynil
Drug quantification
HPLC
Isoprenylcysteine carboxylmethyltransferase (Icmt)
Preclinical study
Issue Date: 2009
Source: Wang, M., Zhou, J., Casey, P., Khoo, Y.M., Lee, H.S. (2009). A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 877 (5-6) : 553-557. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jchromb.2008.12.067
Abstract: Cysmethynil, a newly identified small molecule inhibitor of isoprenylcysteine carboxylmethyl transferase (Icmt) is involved in the post-translational modification of CaaX proteins. Cysmethynil causes cell death in many human cancer cells in vitro, and inhibits tumor growth in the xenograft mouse model in vivo. A HPLC method for the quantification of cysmethynil in mouse plasma was developed and validated. The lower limit of quantification of this method was 0.01 μg/ml. Inter- and intra-day variability ranged from 0.38-8.5% and accuracy was between 86% and 98%. This sensitive method was used to quantify cysmethynil in plasma of mice after intraperitoneal dosing for preliminary pharmacokinetic studies. © 2009 Elsevier B.V. All rights reserved.
Source Title: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
URI: http://scholarbank.nus.edu.sg/handle/10635/27292
ISSN: 15700232
DOI: 10.1016/j.jchromb.2008.12.067
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