Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ejphar.2007.05.003
Title: Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat
Authors: Sidhapuriwala, J. 
Li, L. 
Bhatia, M. 
Moore, P.K. 
Sparatore, A.
Keywords: Diclofenac
Hindpaw
Hydrogen sulfide
Myeloperoxidase
Oedema
S-diclofenac
Issue Date: 2007
Citation: Sidhapuriwala, J., Li, L., Bhatia, M., Moore, P.K., Sparatore, A. (2007). Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat. European Journal of Pharmacology 569 (1-2) : 149-154. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejphar.2007.05.003
Abstract: S-diclofenac (2-[(2,6-dichlorophenyl)amino]benzeneacetic acid 4-(3H-1,2-dithiole-3-thione-5-yl)-phenyl ester) is a novel derivative of diclofenac which, in vivo, undergoes enzymatic cleavage of its ester linkage to release hydrogen sulfide (H2S) along with the parent moiety, diclofenac. In this study the anti-inflammatory activity of S-diclofenac and diclofenac was studied in a carrageenan-evoked hindpaw oedema model in the rat. Drugs or vehicle were administered 3 h before carrageenan. Both drugs produced a dose-dependent anti-inflammatory effect in this model. However, S-diclofenac (ED30, 14.2 ± 0.6 μmol/kg) was more potent (P < 0.05) than diclofenac (ED30, 39.3 ± 1.4 μmol/kg) as an inhibitor both of hindpaw swelling and in reducing the carrageenan-evoked rise in hindpaw myeloperoxidase activity reflecting tissue neutrophil infiltration (ED50s of 12.0 ± 2.1 μmol/kg and 21.9 ± 2.0 μmol/kg). Intraplantar carrageenan injection also significantly (P < 0.05) increased hindpaw concentrations of prostaglandin E2 (PGE2), nitrite/nitrate and H2S synthesizing activity measured at 6 h. Both S-diclofenac and diclofenac pretreatment reduced the carrageenan-induced rise in hindpaw PGE2, nitrite/nitrate and H2S synthesizing activity. Whilst treatment with either drug produced similar inhibition of hindpaw PGE2 and H2S synthesizing activity - S-diclofenac more effectively reduced hindpaw nitrite/nitrate concentration than did diclofenac. It is proposed that the enhanced anti-inflammatory effect of S-diclofenac relates to its ability to release H2S at the inflamed site. These data provide evidence for an anti-inflammatory effect of H2S. © 2007 Elsevier B.V. All rights reserved.
Source Title: European Journal of Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/27216
ISSN: 00142999
DOI: 10.1016/j.ejphar.2007.05.003
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

54
checked on Dec 12, 2018

WEB OF SCIENCETM
Citations

46
checked on Dec 4, 2018

Page view(s)

176
checked on Nov 3, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.