Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.critrevonc.2008.10.008
Title: Retroviral integration sites (RIS) mark cis-regulatory elements
Authors: Ng, C.E.L.
Ito, Y. 
Osato, M. 
Keywords: Enhancer
Gene therapy
Hox
Pu.1
Retroviral insertional mutagenesis
Runx
Wnt-1
Issue Date: 2009
Source: Ng, C.E.L., Ito, Y., Osato, M. (2009). Retroviral integration sites (RIS) mark cis-regulatory elements. Critical Reviews in Oncology/Hematology 71 (1) : 1-11. ScholarBank@NUS Repository. https://doi.org/10.1016/j.critrevonc.2008.10.008
Abstract: Transcription in multicellular eukaryotic organisms involves an elaborate orchestration of the core promoter and cis-regulatory elements to drive spatiotemporally and quantitatively correct gene expression. Unlike promoters found immediately upstream of protein-coding genes, the positions of distally located cis-regulatory elements relative to a gene of interest are difficult to define. As such, the identification and characterization of these regulatory elements has proved to be challenging. To this end, we propose a combinatorial in silico approach involving retroviral integration sites (RIS) mapping together with predicted matrix attachment regions (MARs) mapping and an already well-established comparative genomics approach, to enhance the prediction of potential cis-regulatory elements. Predicted elements can be validated by further investigations to ascertain their functions. In view of the abundance of electronically available RIS information, RIS mapping has an unrealized potential to aid in the discovery of novel cis-regulatory elements. © 2008 Elsevier Ireland Ltd. All rights reserved.
Source Title: Critical Reviews in Oncology/Hematology
URI: http://scholarbank.nus.edu.sg/handle/10635/27177
ISSN: 10408428
DOI: 10.1016/j.critrevonc.2008.10.008
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

1
checked on Dec 14, 2017

WEB OF SCIENCETM
Citations

1
checked on Nov 18, 2017

Page view(s)

208
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.