Please use this identifier to cite or link to this item:
|Title:||Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation|
Cortical spreading depression
Familial hemiplegic migraine
|Source:||Chan, Y.-C., Wilder-Smith, E., Sharma, V., Ong, B.K.C., Burgunder, J.-M., Chew, S.-E., Lam-Mok-Sing, K.M.J. (2008). Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation. Journal of Clinical Neuroscience 15 (8) : 891-894. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jocn.2007.01.013|
|Abstract:||The S218L CACNA1A mutation has been previously described in two families with familial hemiplegic migraine. We present three siblings with the mutation with the novel association of childhood seizures, and highlight the dynamic changes seen on electroencephalography during hemiplegic migraine attacks. Depressed activity contralateral to the hemiparesis was seen on electroencephalography during acute hemiplegic migraine attacks, which may be due to changes to calcium channels caused by the S218L mutation. Both parents were asymptomatic and did not carry the S218L mutation in their blood. This suggests the presence of mosaicism in the transmitting parent. © 2007 Elsevier Ltd. All rights reserved.|
|Source Title:||Journal of Clinical Neuroscience|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 7, 2018
WEB OF SCIENCETM
checked on Feb 5, 2018
checked on Mar 11, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.