Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jocn.2007.01.013
Title: Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation
Authors: Chan, Y.-C.
Wilder-Smith, E. 
Sharma, V.
Ong, B.K.C. 
Burgunder, J.-M. 
Chew, S.-E.
Lam-Mok-Sing, K.M.J. 
Keywords: CACNA1A gene
Cortical spreading depression
Electroencephalography
Familial hemiplegic migraine
Germline mosaicism
S218L
Seizure
Issue Date: 2008
Source: Chan, Y.-C., Wilder-Smith, E., Sharma, V., Ong, B.K.C., Burgunder, J.-M., Chew, S.-E., Lam-Mok-Sing, K.M.J. (2008). Electroencephalographic changes and seizures in familial hemiplegic migraine patients with the CACNA1A gene S218L mutation. Journal of Clinical Neuroscience 15 (8) : 891-894. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jocn.2007.01.013
Abstract: The S218L CACNA1A mutation has been previously described in two families with familial hemiplegic migraine. We present three siblings with the mutation with the novel association of childhood seizures, and highlight the dynamic changes seen on electroencephalography during hemiplegic migraine attacks. Depressed activity contralateral to the hemiparesis was seen on electroencephalography during acute hemiplegic migraine attacks, which may be due to changes to calcium channels caused by the S218L mutation. Both parents were asymptomatic and did not carry the S218L mutation in their blood. This suggests the presence of mosaicism in the transmitting parent. © 2007 Elsevier Ltd. All rights reserved.
Source Title: Journal of Clinical Neuroscience
URI: http://scholarbank.nus.edu.sg/handle/10635/27096
ISSN: 09675868
DOI: 10.1016/j.jocn.2007.01.013
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