Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1549-8719.2010.00021.x
Title: Retinal vessel caliber and peripheral neuropathy in diabetic participants
Authors: CHARUMATHI SABANAYAGAM 
TAI E SHYONG 
LEE JEN-MAI,JEANNETTE 
LIM SU CHI 
Wong Tien Yin 
Keywords: Science & Technology
Life Sciences & Biomedicine
Hematology
Peripheral Vascular Disease
Cardiovascular System & Cardiology
diabetes mellitus
retinal vascular caliber
peripheral neuropathy
VASCULAR CALIBER
RETINOPATHY
DIAMETERS
FOOT
RISK
Issue Date: May-2010
Publisher: WILEY
Citation: CHARUMATHI SABANAYAGAM, TAI E SHYONG, LEE JEN-MAI,JEANNETTE, LIM SU CHI, Wong Tien Yin (2010-05). Retinal vessel caliber and peripheral neuropathy in diabetic participants. Microcirculation 17 (4) : 297-302. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1549-8719.2010.00021.x
Abstract: Background: Retinal vascular caliber changes predict diabetic microvascular complications such as retinopathy, and nephropathy. However, the association between retinal vasculature and peripheral neuropathy is not well studied. Methods: We evaluated the association between retinal vascular caliber and peripheral neuropathy in a multi-ethnic Asian population with diabetes (n = 423) in Singapore. Retinal arteriolar and venular caliber was measured from digital retinal photographs and summarized as central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent. Peripheral neuropathy was defined from neurothesiometer or monofilament sensory testing. Results: Larger CRAE was positively associated with peripheral neuropathy independent of age, sex, ethnicity, current smoking, alcohol consumption, body mass index, total cholesterol, systolic blood pressure, and duration of diabetes. The multivariable odds ratio (OR) [95% confidence interval (CI)] of peripheral neuropathy was 2.81 (1.38-5.73) comparing highest vs. lower three quartiles of CRAE. This association was consistently present in analyses stratified by age, sex and ethnicity. Retinal venular caliber was not associated with peripheral neuropathy. Conclusions: These data suggest that larger retinal arteriolar diameters are associated with peripheral neuropathy independent of major risk factors. © 2010 John Wiley & Sons Ltd.
Source Title: Microcirculation
URI: http://scholarbank.nus.edu.sg/handle/10635/26589
ISSN: 10739688
15498719
DOI: 10.1111/j.1549-8719.2010.00021.x
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