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https://doi.org/10.1111/j.1549-8719.2010.00021.x
Title: | Retinal vessel caliber and peripheral neuropathy in diabetic participants | Authors: | CHARUMATHI SABANAYAGAM TAI E SHYONG LEE JEN-MAI,JEANNETTE LIM SU CHI Wong Tien Yin |
Keywords: | Science & Technology Life Sciences & Biomedicine Hematology Peripheral Vascular Disease Cardiovascular System & Cardiology diabetes mellitus retinal vascular caliber peripheral neuropathy VASCULAR CALIBER RETINOPATHY DIAMETERS FOOT RISK |
Issue Date: | May-2010 | Publisher: | WILEY | Citation: | CHARUMATHI SABANAYAGAM, TAI E SHYONG, LEE JEN-MAI,JEANNETTE, LIM SU CHI, Wong Tien Yin (2010-05). Retinal vessel caliber and peripheral neuropathy in diabetic participants. Microcirculation 17 (4) : 297-302. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1549-8719.2010.00021.x | Abstract: | Background: Retinal vascular caliber changes predict diabetic microvascular complications such as retinopathy, and nephropathy. However, the association between retinal vasculature and peripheral neuropathy is not well studied. Methods: We evaluated the association between retinal vascular caliber and peripheral neuropathy in a multi-ethnic Asian population with diabetes (n = 423) in Singapore. Retinal arteriolar and venular caliber was measured from digital retinal photographs and summarized as central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent. Peripheral neuropathy was defined from neurothesiometer or monofilament sensory testing. Results: Larger CRAE was positively associated with peripheral neuropathy independent of age, sex, ethnicity, current smoking, alcohol consumption, body mass index, total cholesterol, systolic blood pressure, and duration of diabetes. The multivariable odds ratio (OR) [95% confidence interval (CI)] of peripheral neuropathy was 2.81 (1.38-5.73) comparing highest vs. lower three quartiles of CRAE. This association was consistently present in analyses stratified by age, sex and ethnicity. Retinal venular caliber was not associated with peripheral neuropathy. Conclusions: These data suggest that larger retinal arteriolar diameters are associated with peripheral neuropathy independent of major risk factors. © 2010 John Wiley & Sons Ltd. | Source Title: | Microcirculation | URI: | http://scholarbank.nus.edu.sg/handle/10635/26589 | ISSN: | 10739688 15498719 |
DOI: | 10.1111/j.1549-8719.2010.00021.x |
Appears in Collections: | Staff Publications Elements |
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