Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.fertnstert.2005.11.042
Title: The search for factors in human feeders that support the derivation and propagation of human embryonic stem cells: preliminary studies using transcriptome profiling by serial analysis of gene expression
Authors: Kueh, J.
Richards, M. 
Ng, S.-W.
Bongso, A. 
Chan, W.-K. 
Issue Date: 2006
Source: Kueh, J., Richards, M., Ng, S.-W., Bongso, A., Chan, W.-K. (2006). The search for factors in human feeders that support the derivation and propagation of human embryonic stem cells: preliminary studies using transcriptome profiling by serial analysis of gene expression. Fertility and Sterility 85 (6) : 1843-1846. ScholarBank@NUS Repository. https://doi.org/10.1016/j.fertnstert.2005.11.042
Abstract: Serial analysis of gene expression (SAGE) was used to obtain the transcriptome profiles of a supportive human fetal skin feeder (Detroit 551) and a nonsupportive human fetal lung feeder (MRC-5) for human embryonic stem cells. A pairwise comparison of the two SAGE profiles showed that fibroblast growth factor-2 (FGF2), a bone morphogenetic protein 4 pathway inhibitor, Gremlin 1, and several extracellular matrix proteins that could potentially aid human embryonic stem cell attachment and growth were highly expressed in Detroit 551 fibroblasts. © 2006 American Society for Reproductive Medicine.
Source Title: Fertility and Sterility
URI: http://scholarbank.nus.edu.sg/handle/10635/26107
ISSN: 00150282
DOI: 10.1016/j.fertnstert.2005.11.042
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