Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biocel.2008.02.009
Title: Decorin derived antiangiogenic peptide LRR5 inhibits endothelial cell migration by interfering with VEGF-stimulated NO release
Authors: Fan, H. 
Sulochana, K.N.
Ge, R. 
Chong, Y.-S. 
Keywords: Decorin
Endothelial cell migration
NO
PI3K-Akt-eNOS signaling
VEGF
Issue Date: 2008
Source: Fan, H., Sulochana, K.N., Ge, R., Chong, Y.-S. (2008). Decorin derived antiangiogenic peptide LRR5 inhibits endothelial cell migration by interfering with VEGF-stimulated NO release. International Journal of Biochemistry and Cell Biology 40 (10) : 2120-2128. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2008.02.009
Abstract: Excessive angiogenesis plays critical roles in many human diseases including cancer. We have previously shown that human decorin derived 26 amino acids peptide Leucine Rich Repeat 5 (LRR5) inhibits multiple aspects of angiogenesis including vascular endothelial growth factor (VEGF) stimulated migration of endothelial cells (ECs). In this study, we have characterized the molecular mechanism of LRR5 which reveals that its anti-migratory effect on ECs is mediated by inhibiting VEGF-stimulated endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) release. LRR5 carried out this function through signaling pathways that involves PI3 kinase and Akt, but not ERK. This anti-NO release effect is mediated by the C-terminal 13 amino acids of LRR5, correlating with the anti-migratory function of this region. © 2008 Elsevier Ltd. All rights reserved.
Source Title: International Journal of Biochemistry and Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/26102
ISSN: 13572725
DOI: 10.1016/j.biocel.2008.02.009
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