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Title: Application of micro-solid-phase extraction for the determination of persistent organic pollutants in tissue samples
Authors: Basheer, C. 
Yin, M.
Lee, H.K. 
Narasimhan, K. 
Zhao, C.
Choolani, M. 
Keywords: Micro-solid phase extraction
Microwave-assisted extraction
Ovarian cancer
Persistent organic pollutants
Issue Date: 2008
Source: Basheer, C., Yin, M., Lee, H.K., Narasimhan, K., Zhao, C., Choolani, M. (2008). Application of micro-solid-phase extraction for the determination of persistent organic pollutants in tissue samples. Journal of Chromatography A 1186 (1-2) : 358-364. ScholarBank@NUS Repository.
Abstract: A novel, simple and efficient method for determining persistent organic pollutants (POPs) in tissue samples has been developed. This technique involves the use of simultaneous microwave-assisted digestion (MAD) and micro-solid-phase extraction (μ-SPE), in which the sorbent is held within a propylene membrane envelope, with gas chromatographic-mass spectrometric (GC-MS) analysis. The POPs studied included eleven organochlorine pesticides and five polychlorinated biphenyl congeners. Optimization of the MAD-μ-SPE parameters was performed. The relative standard deviations (RSDs) of the method ranged from 0.14 to 12.7%. Correlation coefficients up to 0.9999 were obtained across a concentration range of 1.25-50 ng g-1. The method detection limits for POPs ranged from 0.002 to 0.009 ng g-1. A preliminary study applying the MAD-μ-SPE procedure to human ovarian cancer tissue showed that it was capable of detecting the presence of a wide spectrum of different POPs in benign and malignant tumors. © 2007 Elsevier B.V. All rights reserved.
Source Title: Journal of Chromatography A
ISSN: 00219673
DOI: 10.1016/j.chroma.2007.10.015
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