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Title: Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction - A pilot study
Authors: Srilatha, B. 
Adaikan, P.G. 
Moore, P.K. 
Keywords: (Rat)
Corpus cavernosum
Erectile dysfunction
Hydrogen sulphide
Intracavernous pressure
Issue Date: 2006
Source: Srilatha, B.,Adaikan, P.G.,Moore, P.K. (2006). Possible role for the novel gasotransmitter hydrogen sulphide in erectile dysfunction - A pilot study. European Journal of Pharmacology 535 (1-3) : 280-282. ScholarBank@NUS Repository.
Abstract: Penile erectile tissue is a highly vascularised smooth muscle which hitherto has been an unexplored target for the neuromodulatory effect of hydrogen sulphide. In this study, intracavernous injection of sodium hydrogen sulphide to primates resulted in significant increases in penile length and cavernous pressure. In another set of experiments, administration of dl-propargylglycine (inhibitor of cystathionine γ-lyase) to rats resulted in significant reduction in cavernous nerve stimulation-evoked perfusion pressure. Our pilot experiment suggests a possible role for endogenous hydrogen sulphide in erectile physiopharmacology through facilitation of nerve-mediated penile tumescence; this is confirmed by the inhibitory effect of propargylglycine on the proerectile pathway. © 2006 Elsevier B.V. All rights reserved.
Source Title: European Journal of Pharmacology
ISSN: 00142999
DOI: 10.1016/j.ejphar.2006.02.001
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