Please use this identifier to cite or link to this item:
|Title:||Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species|
|Authors:||Shen, P. |
|Citation:||Shen, P., Gong, Y., Yong, E.L., Guo, B.L., Hong, D.Y.Q., Hong, Y. (2007). Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Phytochemistry 68 (10) : 1448-1458. ScholarBank@NUS Repository. https://doi.org/10.1016/j.phytochem.2007.03.001|
|Abstract:||To understand the factors contributing to estrogenic properties of extracts from the genus Epimedium L. (Berberidaceae), we performed taxonomic, genetic and chemical characterization on 37 specimens from 18 species and related these to estrogen receptor (ERα and ERβ) bioactivity, as measured by reporter genes in stable human cells. Boot strap values derived from amplified fragment length polymorphisms indicated that specimens of E. koreanum, E. brevicornum, E. myrianthum, E. leishanense, and E. membranaceum were genetically distinct and this was supported by their very similar ERα activities. In contrast, specimens from E. pubescens and E. sagittatum were diverse both genetically, chemically and in terms of ERα and ERβ bioactivities. Strikingly, a genetic cluster comprising six rare Epimedium species exhibited strongest ERα and ERβ activity, and this bioactivity was positively correlated with content of trace flavonoid aglycones (kaempferol, apigenin, quercetin, luteolin and breviflavone B). In contrast, there was no association between estrogenic activity and the major flavonol glycoside constituents (icariin and epimedin A-C). Although they exhibited equally strong ERα and ERβ activity, E. koreanum can be clearly differentiated from E. pubescens and E. brevicornum by genetic distance and its significantly lower content of epimedin C. Our morphologic, genetic, chemical and bioactivity profiling provide the basis for the production of extracts with reproducible estrogenic properties. Such reproducibility will be critical for the standardization of Epimedium-based products. © 2007 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 24, 2018
WEB OF SCIENCETM
checked on Sep 17, 2018
checked on Sep 22, 2018
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.