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|Title:||A prospective, randomized comparison of vaginal misoprostol versus intra-amniotic prostaglandins for midtrimester termination of pregnancy|
Randomized, controlled trial
Second-trimester pregnancy termination
|Citation:||Su, L.-L., Biswas, A., Choolani, M., Kalaichelvan, V., Singh, K. (2005). A prospective, randomized comparison of vaginal misoprostol versus intra-amniotic prostaglandins for midtrimester termination of pregnancy. American Journal of Obstetrics and Gynecology 193 (4) : 1410-1414. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ajog.2005.02.082|
|Abstract:||Objective: The purpose of this study was to compare the efficacy and adverse effects of vaginal misoprostol and intra-amniotic PGF2α for midtrimester abortion. Study design: One hundred thirty-two women between 12 and 24 weeks' gestation, seeking abortion in a tertiary hospital, were randomized to receive vaginal misoprostol (400 μg every 3 hours) or intra-amniotic PGF2α (carboprost 1.5 mg). Main outcome measures were induction-to-abortion interval, success rates at 24 and 48 hours, and adverse effects. Results: Successful abortion rates at 24 and 48 hours between intra-amniotic PGF2α and vaginal misoprostol were not statistically different. However, vaginal misoprostol results in a significantly shorter mean induction-to-abortion interval, compared with intra-amniotic PGF2α (misoprostol: 16.2 hours; intra-amniotic PGF 2α: 20.8 hours; P = .006), particularly among multiparous women (misoprostol: 13.1 hours; intra-amniotic PGF2α 18.3 hours; P = .011) and for gestation below 130 days (misoprostol: 14.6 hours; intra-amniotic PGF2α: 20.2 hours; P = .015). Fever and shivering were commoner with vaginal misoprostol. Conclusion: Vaginal misoprostol should be the regimen of choice for midtrimester abortion, particularly for multiparous women and women in the early second trimester. © 2005 Elsevier Inc. All rights reserved.|
|Source Title:||American Journal of Obstetrics and Gynecology|
|Appears in Collections:||Staff Publications|
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