Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ajog.2005.02.082
Title: A prospective, randomized comparison of vaginal misoprostol versus intra-amniotic prostaglandins for midtrimester termination of pregnancy
Authors: Su, L.-L.
Biswas, A. 
Choolani, M. 
Kalaichelvan, V.
Singh, K. 
Keywords: Intra-amniotic prostaglandins
Randomized, controlled trial
Second-trimester pregnancy termination
Vaginal misoprostol
Issue Date: 2005
Source: Su, L.-L., Biswas, A., Choolani, M., Kalaichelvan, V., Singh, K. (2005). A prospective, randomized comparison of vaginal misoprostol versus intra-amniotic prostaglandins for midtrimester termination of pregnancy. American Journal of Obstetrics and Gynecology 193 (4) : 1410-1414. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ajog.2005.02.082
Abstract: Objective: The purpose of this study was to compare the efficacy and adverse effects of vaginal misoprostol and intra-amniotic PGF2α for midtrimester abortion. Study design: One hundred thirty-two women between 12 and 24 weeks' gestation, seeking abortion in a tertiary hospital, were randomized to receive vaginal misoprostol (400 μg every 3 hours) or intra-amniotic PGF2α (carboprost 1.5 mg). Main outcome measures were induction-to-abortion interval, success rates at 24 and 48 hours, and adverse effects. Results: Successful abortion rates at 24 and 48 hours between intra-amniotic PGF2α and vaginal misoprostol were not statistically different. However, vaginal misoprostol results in a significantly shorter mean induction-to-abortion interval, compared with intra-amniotic PGF2α (misoprostol: 16.2 hours; intra-amniotic PGF 2α: 20.8 hours; P = .006), particularly among multiparous women (misoprostol: 13.1 hours; intra-amniotic PGF2α 18.3 hours; P = .011) and for gestation below 130 days (misoprostol: 14.6 hours; intra-amniotic PGF2α: 20.2 hours; P = .015). Fever and shivering were commoner with vaginal misoprostol. Conclusion: Vaginal misoprostol should be the regimen of choice for midtrimester abortion, particularly for multiparous women and women in the early second trimester. © 2005 Elsevier Inc. All rights reserved.
Source Title: American Journal of Obstetrics and Gynecology
URI: http://scholarbank.nus.edu.sg/handle/10635/26002
ISSN: 00029378
DOI: 10.1016/j.ajog.2005.02.082
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

16
checked on Dec 7, 2017

WEB OF SCIENCETM
Citations

15
checked on Nov 23, 2017

Page view(s)

175
checked on Dec 11, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.