Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.rmed.2006.08.012
Title: Eosinophil cationic protein: Is it useful in asthma? A systematic review
Authors: Koh, G.C.-H.
Koh, D.S.-Q.
Shek, L.P.-C. 
Goh, D.Y.-T.
Van, Bever H. 
Keywords: Asthma
Biological marker
ECP
Eosinophil cationic protein
Systematic review
Issue Date: 2007
Source: Koh, G.C.-H., Koh, D.S.-Q., Shek, L.P.-C., Goh, D.Y.-T., Van, Bever H. (2007). Eosinophil cationic protein: Is it useful in asthma? A systematic review. Respiratory Medicine 101 (4) : 696-705. ScholarBank@NUS Repository. https://doi.org/10.1016/j.rmed.2006.08.012
Abstract: Introduction: Eosinophil cationic protein (ECP) has been widely investigated as a potential biomarker of airway inflammation. Method: A systematic review was performed using Medline with key terms eosinophil cationic protein and asthma, limiting the search to titles or abstracts. Out of 688 potential papers found, abstracts were reviewed based on the following criteria: (1) ECP was used as a biological marker, (2) asthma was the index disease studied, (3) it was a controlled clinical study and (4) ECP was assessed as a diagnostic, assessment or management tool. One hundred and sixty-nine articles satisfied the selection criteria and their full-text versions were reviewed. Only 53 papers were found to provide clinically useful information. Results: ECP has been measured in serum, plasma, sputum, saliva and broncho-alveolar lavage fluids but serum and sputum are the most established. Levels of ECP in normal and asthmatic subjects in various body fluids were identified. ECP correlates well with airway inflammation but not airway hyper-responsiveness. It is raised in other atopic diseases and hence is not diagnostic for asthma. However, it has been shown to be useful in assessing asthma severity, compliance with anti-inflammatory asthma therapy and as a guide to tailing down inhaled corticosteroid therapy. Although there is some evidence that ECP levels are affected by age, smoking, circadian rhythm and seasonal variation, only smoking appears to be of clinical significance. Discussion: Despite its limitations, ECP remains potentially useful in asthma management. Future research on ECP should focus on using serial measurements and combining it with other markers of asthma which may increase its clinical usefulness. © 2006 Elsevier Ltd. All rights reserved.
Source Title: Respiratory Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/25739
ISSN: 09546111
DOI: 10.1016/j.rmed.2006.08.012
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

82
checked on Dec 11, 2017

WEB OF SCIENCETM
Citations

76
checked on Dec 11, 2017

Page view(s)

189
checked on Dec 9, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.