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|Title:||Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children|
Live attenuated influenza vaccine
|Citation:||Lum, L.C.S., Borja-Tabora, C.F., Breiman, R.F., Brooks, W.A., Vesikari, T., Sablan, B.P., Chay, O.M., Tantracheewathorn, T., Schmitt, H.-J., Lau, Y.-L., Bowonkiratikachorn, P., Tam, J.S., Lee, B.W., Tan, K.K., Pejcz, J., Cha, S., Gutierrez-Brito, M., Kaltenis, P., Vertruyen, A., Czajka, H., Bojarskas, J., Cheng, S.-M., Rappaport, R., Baker, S., Gruber, W.C., Forrest, B.D. (2010). Influenza vaccine concurrently administered with a combination measles, mumps, and rubella vaccine to young children. Vaccine 28 (6) : 1566-1574. ScholarBank@NUS Repository. https://doi.org/10.1016/j.vaccine.2009.11.054|
|Abstract:||Children aged 11 to <24 months received 2 intranasal doses of live attenuated influenza vaccine (LAIV) or placebo, 35 ± 7 days apart. Dose 1 was administered concomitantly with a combined measles, mumps, and rubella vaccine (Priorix). Seroresponses to measles and mumps were similar between groups. Compared with placebo, response rates to rubella in LAIV + Priorix recipients were statistically lower at a 15 IU/mL threshold (83.9% vs 78.0%) and the prespecified noninferiority criteria were not met. In a post hoc analysis using an alternate widely accepted threshold of 10 IU/mL, the noninferiority criteria were met (93.4% vs 89.8%). Concomitant administration with Priorix did not affect the overall influenza protection rate of LAIV (78.4% and 63.8% against antigenically similar influenza strains and any strain, respectively). © 2009 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Staff Publications|
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