Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.leukres.2009.07.003
Title: Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group
Authors: Yeoh, A.E.-J.
Lu, Y. 
Chan, J.Y.-S.
Kham, S.K.-Y.
Quah, T.C. 
Chan, Y.H.
Ariffin, H.
Keywords: Childhood ALL
Folate metabolism
Gender effect
Genetic epidemiology
Malay
NQO1
Polymorphism
Issue Date: 2010
Source: Yeoh, A.E.-J., Lu, Y., Chan, J.Y.-S., Kham, S.K.-Y., Quah, T.C., Chan, Y.H., Ariffin, H. (2010). Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group. Leukemia Research 34 (3) : 276-283. ScholarBank@NUS Repository. https://doi.org/10.1016/j.leukres.2009.07.003
Abstract: To study genetic epidemiology of childhood acute lymphoblastic leukemia (ALL) in the Chinese and Malays, we investigated 10 polymorphisms encoding carcinogen- or folate-metabolism and transport. Sex-adjusted analysis showed NQO1 609CT significantly protects against ALL, whilst MTHFR 677CT confers marginal protection. Interestingly, we observed that NQO1 609CT and MTHFR 1298 C-allele have greater genetic impact in boys than in girls. The combination of SLC19A1 80GA heterozygosity and 3′-TYMS -6 bp/-6 bp homozygous deletion is associated with reduced ALL risk in Malay boys. Our study has suggested the importance of gender and race in modulating ALL susceptibility via the folate metabolic pathway. © 2009 Elsevier Ltd.
Source Title: Leukemia Research
URI: http://scholarbank.nus.edu.sg/handle/10635/25622
ISSN: 01452126
DOI: 10.1016/j.leukres.2009.07.003
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