Please use this identifier to cite or link to this item:
|Title:||Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis|
Heparin-binding growth factor
|Citation:||Jackson, R.A., Nurcombe, V., Cool, S.M. (2006). Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis. Gene 379 (1-2) : 79-91. ScholarBank@NUS Repository. https://doi.org/10.1016/j.gene.2006.04.028|
|Abstract:||Growth and lineage-specific differentiation constitute crucial phases in the development of stem cells. Control over these processes is exerted by particular elements of the extracellular matrix, which ultimately trigger a cascade of signals that regulate uncommitted cells, by modulating their survival and cell cycle progression, to shape developmental processes. Uncontrolled, constitutive activation of fibroblast growth factor receptors (FGFR) results in bone abnormalities, underlining the stringent control over fibroblast growth factor (FGF) activity that must be maintained for normal osteogenesis to proceed. Mounting evidence suggests that FGF signalling, together with a large number of other growth and adhesive factors, is controlled by the extracellular glycosaminoglycan sugar, heparan sulfate (HS). In this review, we focus on FGF activity during osteogenesis, their receptors, and the use of HS as a therapeutic adjuvant for bone repair. © 2006 Elsevier B.V. All rights reserved.|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Mar 23, 2019
WEB OF SCIENCETM
checked on Mar 13, 2019
checked on Jan 13, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.