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|Title:||Sharp-1 modulates the cellular response to DNA damage|
|Authors:||Liu, J.-J. |
|Source:||Liu, J.-J., Chung, T.-K., Taneja, R., Li, J. (2010). Sharp-1 modulates the cellular response to DNA damage. FEBS Letters 584 (3) : 619-624. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2009.12.011|
|Abstract:||DNA damage checkpoints are essential for maintenance of genome integrity. We report here that inducible overexpression of the transcription factor Sharp-1 results in an S and G2/M cell cycle arrest, concomitant with the upregulation of Brca1 and GADD45α expression. In addition, we show that endogenous Sharp-1 mRNA is increased by DNA-damaging agents. Consistently, Sharp-1 overexpressing cells exhibit reduced apoptosis in response to chemotherapeutic drugs along with lower p53 expression and activity. Our studies identify a novel function for Sharp-1 in cell cycle arrest and DNA damage-induced apoptosis. Inappropriate Sharp-1 expression may therefore be associated with tumorigenesis. © 2009 Federation of European Biochemical Societies.|
|Source Title:||FEBS Letters|
|Appears in Collections:||Staff Publications|
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