Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.febslet.2009.12.011
Title: Sharp-1 modulates the cellular response to DNA damage
Authors: Liu, J.-J. 
Chung, T.-K. 
Taneja, R. 
Li, J.
Keywords: Apoptosis
Dec2
DNA damage
Growth arrest
Issue Date: 2010
Source: Liu, J.-J., Chung, T.-K., Taneja, R., Li, J. (2010). Sharp-1 modulates the cellular response to DNA damage. FEBS Letters 584 (3) : 619-624. ScholarBank@NUS Repository. https://doi.org/10.1016/j.febslet.2009.12.011
Abstract: DNA damage checkpoints are essential for maintenance of genome integrity. We report here that inducible overexpression of the transcription factor Sharp-1 results in an S and G2/M cell cycle arrest, concomitant with the upregulation of Brca1 and GADD45α expression. In addition, we show that endogenous Sharp-1 mRNA is increased by DNA-damaging agents. Consistently, Sharp-1 overexpressing cells exhibit reduced apoptosis in response to chemotherapeutic drugs along with lower p53 expression and activity. Our studies identify a novel function for Sharp-1 in cell cycle arrest and DNA damage-induced apoptosis. Inappropriate Sharp-1 expression may therefore be associated with tumorigenesis. © 2009 Federation of European Biochemical Societies.
Source Title: FEBS Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/25145
ISSN: 00145793
DOI: 10.1016/j.febslet.2009.12.011
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