Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.gene.2005.08.022
Title: Comparative genomics of the human and Fugu voltage-gated calcium channel α1-subunit gene family reveals greater diversity in Fugu
Authors: Wong, E.
Soong, T.W. 
Yu, W.-P.
Yap, W.H.
Venkatesh, B. 
Keywords: Conserved synteny
Gene duplication
Phylogenetic analysis
Tissue distribution
Issue Date: 2006
Source: Wong, E., Soong, T.W., Yu, W.-P., Yap, W.H., Venkatesh, B. (2006). Comparative genomics of the human and Fugu voltage-gated calcium channel α1-subunit gene family reveals greater diversity in Fugu. Gene 366 (1) : 117-127. ScholarBank@NUS Repository. https://doi.org/10.1016/j.gene.2005.08.022
Abstract: Extensive search for the orthologs of 10 human voltage-gated calcium channel (VGCC) α1-subunit genes in the Fugu genome sequence revealed 21 α1-subunit genes in the compact genome of Fugu. Subtype classification of the identified Fugu α1 orthologs based on phylogenetic analysis, genomic organization and sequence comparison of the most divergent II/III loop and the C-terminal regions of the α1-subunits indicated extra copies of α1S-, α1D-, α1F-, α1A-, α1E-, α1H- and α1G-subunit genes. Phylogenetic analysis reveals that this is likely due to fish lineage specific α1-subunit subtype duplication. Sequence comparison shows that many of the structural features characteristic of VGCC and specific channel subtypes are also present in the Fugu α1-subunits. All the Fugu α1-subunits showed similar expression profile to that of the mammalian α1-subunits except for Fugu α1S, α1A, α1B and α1H which have a more widespread tissue distribution. These results indicate that Fugu, a lower vertebrate, has more extensive channel heterogeneity compared to human. © 2005 Elsevier B.V. All rights reserved.
Source Title: Gene
URI: http://scholarbank.nus.edu.sg/handle/10635/25122
ISSN: 03781119
DOI: 10.1016/j.gene.2005.08.022
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

6
checked on Dec 14, 2017

WEB OF SCIENCETM
Citations

6
checked on Nov 19, 2017

Page view(s)

160
checked on Dec 17, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.