Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cell.2009.12.024
Title: Mutations in Potassium Channel Kir2.6 Cause Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis
Authors: Ryan, D.P.
Ptacek, L.J.
Dias, da Silva M.R.
Donaldson, M.R.
Soong, T.W. 
Fontaine, B.
Kung, A.W.C.
Jongjaroenprasert, W.
Liang, M.C. 
Cheah, J.S. 
Khoo, D.H.C.
Ho, S.C.
Bernstein, H.S.
Maciel, R.M.B.
Brown, Jr. R.H.
Keywords: HUMDISEASE
PROTEINS
SIGNALING
Issue Date: 2010
Source: Ryan, D.P., Ptacek, L.J., Dias, da Silva M.R., Donaldson, M.R., Soong, T.W., Fontaine, B., Kung, A.W.C., Jongjaroenprasert, W., Liang, M.C., Cheah, J.S., Khoo, D.H.C., Ho, S.C., Bernstein, H.S., Maciel, R.M.B., Brown, Jr. R.H. (2010). Mutations in Potassium Channel Kir2.6 Cause Susceptibility to Thyrotoxic Hypokalemic Periodic Paralysis. Cell 140 (1) : 88-98. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cell.2009.12.024
Abstract: Thyrotoxic hypokalemic periodic paralysis (TPP) is characterized by acute attacks of weakness, hypokalemia, and thyrotoxicosis of various etiologies. These transient attacks resemble those of patients with familial hypokalemic periodic paralysis (hypoKPP) and resolve with treatment of the underlying hyperthyroidism. Because of the phenotypic similarity of these conditions, we hypothesized that TPP might also be a channelopathy. While sequencing candidate genes, we identified a previously unreported gene (not present in human sequence databases) that encodes an inwardly rectifying potassium (Kir) channel, Kir2.6. This channel, nearly identical to Kir2.2, is expressed in skeletal muscle and is transcriptionally regulated by thyroid hormone. Expression of Kir2.6 in mammalian cells revealed normal Kir currents in whole-cell and single-channel recordings. Kir2.6 mutations were present in up to 33% of the unrelated TPP patients in our collection. Some of these mutations clearly alter a variety of Kir2.6 properties, all altering muscle membrane excitability leading to paralysis. © 2010 Elsevier Inc. All rights reserved.
Source Title: Cell
URI: http://scholarbank.nus.edu.sg/handle/10635/25087
ISSN: 00928674
DOI: 10.1016/j.cell.2009.12.024
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