Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/25059
Title: Understanding Dentine Demineralizaion and Development of Strategies for Biomimetic Remineralization of Deminderalized Dentine
Authors: ZHANG XU
Keywords: dentine, demineralization, remineralization, biomimetic, phosphorylation, phosphorylated chitosan
Issue Date: 27-Dec-2010
Source: ZHANG XU (2010-12-27). Understanding Dentine Demineralizaion and Development of Strategies for Biomimetic Remineralization of Deminderalized Dentine. ScholarBank@NUS Repository.
Abstract: Dentine remineralization is clinically significant for prevention and treatment of root caries and dentine hypersensitivity. However, dentine remineralization is more difficult than enamel remineralization due to the abundant organic matrix in dentine. The general objective of this study was to develop a biomimetic method to facilitate remineralization of demineralized dentine. The hypothesis was that by mimicking the nucleating role of phosphorylated noncollageneous proteins (NCPs) in vivo, type I collagen in demineralized dentine can be biomimetically modified to induce marked remineralization. The biomimetic remineralization was carried out using two methods: phosphorylation of the collagen in demineralized dentine using sodium trimetaphosphate (STMP) and covalent immobilization of phosphorylated chitosan (P-chi) on the collagen in demineralized dentine. The experimental results indicated that the biomimetic methodologies resulted in favorable surface properties (i.e. highly negative charge and low interfacial free energy between substrate and aqueous medium) for crystal nucleation, and thus enhanced remineralization of dentine.
URI: http://scholarbank.nus.edu.sg/handle/10635/25059
Appears in Collections:Ph.D Theses (Open)

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