Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mam.2009.12.001
Title: Tumor cell redox state and mitochondria at the center of the non-canonical activity of telomerase reverse transcriptase
Authors: Indran, I.R. 
Hande, M.P. 
Pervaiz, S. 
Keywords: Apoptosis
hTERT
Mitochondria
ROS
Senescence
Issue Date: 2010
Citation: Indran, I.R., Hande, M.P., Pervaiz, S. (2010). Tumor cell redox state and mitochondria at the center of the non-canonical activity of telomerase reverse transcriptase. Molecular Aspects of Medicine 31 (1) : 21-28. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mam.2009.12.001
Abstract: Telomerase (hTERT) activation in cancer cells is an invariable finding resulting in the maintenance of telomere lengths and enhanced replicative capacity. Therefore a variety of therapeutic approaches are being investigated to target hTERT, such as hTERT-promoter driven expression of apoptosis inducing genes, inhibiting telomeric RNA (hTR), and anti-sense or siRNA mediated gene silencing. Whereas, the conventional oncogenic role of hTERT has been linked to its ability to induce replicative senescence and immortalization, evidence is accumulating to support non-canonical activity of hTERT in cancer cells. To that end, hTERT has been implicated in redox-mediated events and its expression has been shown to impact cellular redox status via the recruitment of the mitochondria, a critical intracellular source of reactive oxygen species (ROS). Further evidence in support of the role of mitochondria in hTERT biology comes from findings demonstrating localization of hTERT to the mitochondria, and the ability of hTERT inhibitors to induce mitochondrial-dependent apoptosis in target cells. Here we review the emerging evidence to support the involvement of the mitochondria and intracellular ROS as critical mediators of the non-canonical functions/activity of hTERT with potential implications for its therapeutic targeting in cancer cells. © 2009 Elsevier Ltd. All rights reserved.
Source Title: Molecular Aspects of Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/25025
ISSN: 00982997
DOI: 10.1016/j.mam.2009.12.001
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

21
checked on Nov 20, 2018

WEB OF SCIENCETM
Citations

18
checked on Nov 5, 2018

Page view(s)

199
checked on Nov 10, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.