Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biocel.2010.06.010
Title: Casein Kinase II: An attractive target for anti-cancer drug design
Authors: Hanif, I.M.
Shazib, M.A.
Ahmad, K.A.
Pervaiz, S. 
Keywords: Apoptosis
Cancer
Proliferation
Protein Kinase CK2
Issue Date: 2010
Source: Hanif, I.M., Shazib, M.A., Ahmad, K.A., Pervaiz, S. (2010). Casein Kinase II: An attractive target for anti-cancer drug design. International Journal of Biochemistry and Cell Biology 42 (10) : 1602-1605. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biocel.2010.06.010
Abstract: Casein Kinase II (CK2) is a ubiquitous serine/threonine kinase that is highly conserved in eukaryotic cells. CK2 has been shown to impact cell growth and proliferation, as numerous growth-related proteins are substrates of CK2. More importantly, experimental evidence linking increased expression and activity of CK2 to human cancers underscores the relevance of CK2 biology to cellular transformation and carcinogenesis. Due to the critical regulatory role CK2 plays in cell fate determination in cancer cells, there is a tremendous interest in the development of CK2-specific therapies. Supporting this, recent reports have demonstrated that genetic manipulation of CK2 expression as well as pharmacological inhibition of its enzymatic activity sensitizes cancers to apoptotic stimuli. Here we provide a succinct account of the biology of CK2, its cellular substrates, its pro-survival and pro-proliferation activity, and highlight evidence for its involvement in human cancer. © 2010.
Source Title: International Journal of Biochemistry and Cell Biology
URI: http://scholarbank.nus.edu.sg/handle/10635/24999
ISSN: 13572725
DOI: 10.1016/j.biocel.2010.06.010
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