Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cellsig.2007.04.014
Title: Signal transduction mechanisms of CD137 ligand in human monocytes
Authors: Sollner, L.
Shaqireen, Kwajah M.M.
Wu, J.T. 
Schwarz, H. 
Keywords: CD137 ligand
Human
Monocytes
Signal transduction
Signalling
Issue Date: 2007
Source: Sollner, L., Shaqireen, Kwajah M.M., Wu, J.T., Schwarz, H. (2007). Signal transduction mechanisms of CD137 ligand in human monocytes. Cellular Signalling 19 (9) : 1899-1908. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cellsig.2007.04.014
Abstract: Bidirectional signalling, i.e. simultaneous signalling through a receptor as well as its cell surface-bound ligand has been identified for several members of the TNF and TNF receptor family members. Reverse signalling through the ligands offers the advantage of an immediate feed-back and a more precise fine tuning of biological responses. Little is known about the molecular nature of reverse signalling through the ligands. CD137 ligand, member of the TNF family is expressed on monocytes and induces activation, migration, prolongation of survival and proliferation of monocytes. Here we show that reverse signalling by CD137 ligand is mediated by protein tyrosine kinases, p38 mitogen activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK)1,2, MAP/ERK kinase (MEK), Phosphoinositide-3-kinase (PI3-K) and protein kinase A (PKA) but not by protein kinase C (PKC). This study also shows that reverse signalling relies on the same signal transduction molecules as signalling through classical receptors and is in its nature not different from it. © 2007 Elsevier Inc. All rights reserved.
Source Title: Cellular Signalling
URI: http://scholarbank.nus.edu.sg/handle/10635/24916
ISSN: 08986568
DOI: 10.1016/j.cellsig.2007.04.014
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