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Title: Atomic force microscopy study of the antimicrobial action of Sushi peptides on Gram negative bacteria
Authors: Li, A. 
Lee, P.Y.
Lim, C.T. 
Ho, B. 
Ding, J.L. 
Keywords: Antimicrobial Sushi peptide
Atomic force microscopy
Gram negative bacteria
Issue Date: 2007
Source: Li, A., Lee, P.Y., Lim, C.T., Ho, B., Ding, J.L. (2007). Atomic force microscopy study of the antimicrobial action of Sushi peptides on Gram negative bacteria. Biochimica et Biophysica Acta - Biomembranes 1768 (3) : 411-418. ScholarBank@NUS Repository.
Abstract: The antibacterial effect of the endotoxin-binding Sushi peptides against Gram-negative bacteria (GNB) is investigated in this study. Similar characteristics observed for Atomic force microscopy (AFM) images of peptide-treated Escherichia coli and Pseudomonas aeruginosa suggest that the Sushi peptides (S3) evoke comparable mechanism of action against different strains of GNB. The results also indicate that the Sushi peptides appear to act in three stages: damage of the bacterial outer membrane, permeabilization of the inner membrane and disintegration of both membranes. The AFM approach has provided vivid and detailed close-up images of the GNB undergoing various stages of antimicrobial peptide actions at the nanometer scale. The AFM results support our hypothesis that the S3 peptide perturbs the GNB membrane via the "carpet-model" and thus, provide important insights into their antimicrobial mechanisms. © 2006 Elsevier B.V. All rights reserved.
Source Title: Biochimica et Biophysica Acta - Biomembranes
ISSN: 00052736
DOI: 10.1016/j.bbamem.2006.12.010
Appears in Collections:Staff Publications

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