Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2009.08.108
Title: Specific interaction of capsid protein and importin-α/β influences West Nile virus production
Authors: Bhuvanakantham, R. 
Chong, M.-K. 
Ng, M.-L. 
Keywords: Binding strength
Capsid
Importin
Virus production
Issue Date: 2009
Source: Bhuvanakantham, R., Chong, M.-K., Ng, M.-L. (2009). Specific interaction of capsid protein and importin-α/β influences West Nile virus production. Biochemical and Biophysical Research Communications 389 (1) : 63-69. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2009.08.108
Abstract: West Nile virus (WNV) capsid (C) protein has been shown to enter the nucleus of infected cells. However, the mechanism by which C protein enters the nucleus is unknown. In this study, we have unveiled for the first time that nuclear transport of WNV and Dengue virus C protein is mediated by their direct association with importin-α. This interplay is mediated by the consensus sequences of bipartite nuclear localization signal located between amino acid residues 85-101 together with amino acid residues 42 and 43 of C protein. Elucidation of biological significance of importin-α/C protein interaction demonstrated that the binding efficiency of this association influenced the nuclear entry of C protein and virus production. Collectively, this study illustrated the molecular mechanism by which the C protein of arthropod-borne flavivirus enters the nucleus and showed the importance of importin-α/C protein interaction in the context of flavivirus life-cycle. © 2009 Elsevier Inc. All rights reserved.
Source Title: Biochemical and Biophysical Research Communications
URI: http://scholarbank.nus.edu.sg/handle/10635/24732
ISSN: 0006291X
10902104
DOI: 10.1016/j.bbrc.2009.08.108
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

22
checked on Dec 6, 2017

WEB OF SCIENCETM
Citations

22
checked on Nov 18, 2017

Page view(s)

196
checked on Dec 10, 2017

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.