Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.chempr.2023.04.004
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dc.titleBioorthogonal reactions and AIEgen-based metabolically engineered theranostic systems
dc.contributor.authorKenry
dc.contributor.authorLiu, B
dc.date.accessioned2023-11-17T09:22:42Z
dc.date.available2023-11-17T09:22:42Z
dc.date.issued2023-08-10
dc.identifier.citationKenry, Liu, B (2023-08-10). Bioorthogonal reactions and AIEgen-based metabolically engineered theranostic systems. Chem 9 (8) : 2078-2094. ScholarBank@NUS Repository. https://doi.org/10.1016/j.chempr.2023.04.004
dc.identifier.issn2451-9308
dc.identifier.issn2451-9294
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/246045
dc.description.abstractMetabolic labeling based on bioorthogonal click chemistry has transformed the way living entities are manipulated in biological environments to enable more targeted, effective, and safer theranostic applications. Since the first demonstrations of this strategy, many other metabolic labeling approaches have been formulated to incorporate additional functionalities, such as those based on fluorogens with aggregation-induced emission characteristic (AIEgens), for light-up bioimaging and image-guided disease therapy. In this perspective, we discuss the emergence and development of AIEgen-based theranostic systems for bioorthogonal metabolic engineering and labeling. First, we highlight the fundamental principles guiding the design of AIEgen-based bioorthogonal metabolic labeling. Next, we describe the formulation and applications of different AIEgen-based synthetic and living theranostic systems for cancer and pathogenic bacterial imaging and ablation. We then provide our outlook on the current challenges, potential opportunities, and future research directions of this emerging field.
dc.publisherElsevier BV
dc.sourceElements
dc.typeReview
dc.date.updated2023-11-17T07:20:00Z
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.description.doi10.1016/j.chempr.2023.04.004
dc.description.sourcetitleChem
dc.description.volume9
dc.description.issue8
dc.description.page2078-2094
dc.published.statePublished
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