Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2008.01.006
Title: Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma
Authors: Liu, Z.-M.
Li, L.-Q.
Peng, M.-H.
Liu, T.-W.
Qin, Z.
Guo, Y.
Xiao, K.-Y.
Ye, X.-P.
Mo, X.-S.
Qin, X.
Li, S.
Peng, T.
Yan, L.-N.
Shen, H.-M.
Ong, C.N. 
Wang, L.
Wang, Q.
Santella, R.M.
Peng, T.
Wang, K.-b.
Liang, R.-x.
Wei, Z.-l.
Keywords: Aflatoxin
HBV
Hepatocellular carcinoma
Oxidative stress
Issue Date: 2008
Source: Liu, Z.-M., Li, L.-Q., Peng, M.-H., Liu, T.-W., Qin, Z., Guo, Y., Xiao, K.-Y., Ye, X.-P., Mo, X.-S., Qin, X., Li, S., Peng, T., Yan, L.-N., Shen, H.-M., Ong, C.N., Wang, L., Wang, Q., Santella, R.M., Peng, T., Wang, K.-b., Liang, R.-x., Wei, Z.-l. (2008). Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma. Cancer Letters 263 (2) : 212-222. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2008.01.006
Abstract: Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p < 0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p = 0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region. © 2008 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/24439
ISSN: 03043835
DOI: 10.1016/j.canlet.2008.01.006
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