Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.neulet.2005.12.053
Title: Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury
Authors: Lu, J.
Moochhala, S. 
Ng, K.C.
Tan, M.H.
Lee, L.K.H.
Moore, X.-L.
Wong, M.C.
He, B. 
Ling, E.-A. 
Keywords: Bone marrow cells
Functional recovery
Neural differentiation
Rats
Transplantation
Traumatic brain injury
Issue Date: 2006
Source: Lu, J., Moochhala, S., Ng, K.C., Tan, M.H., Lee, L.K.H., Moore, X.-L., Wong, M.C., He, B., Ling, E.-A. (2006). Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury. Neuroscience Letters 398 (1-2) : 12-17. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2005.12.053
Abstract: This study aims to investigate the therapeutic potential of adult bone marrow stromal cells (BMSCs). Exposed to a cocktail of induction medium, some BMSCs could differentiate into cell types with phenotypes of neural lineages in vitro. These cells expressed neural markers nestin, GFAP, 68-kDa neurofilament and β-tubulin III as detected by immunohistochemistry and RT-PCR. Fluorescence-labeled cells were injected intravenously at 72 h after traumatic brain injury. Transplanted cells survived and migrated to the ipsilateral cerebral cortex at different time points after injection. They were immunopositive for neuronal marker MAP-2, oligodendrocyte marker CNPase, astrocytic maker GFAP or microglial marker OX-42 in vivo. In rats receiving BMSC transplants, there were significant improvements in motor and neurological functions when compared with the control groups. Hence, the therapeutic potential of BMSCs for traumatic brain injury is further amplified. © 2005 Elsevier Ireland Ltd. All rights reserved.
Source Title: Neuroscience Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/24322
ISSN: 03043940
DOI: 10.1016/j.neulet.2005.12.053
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