Please use this identifier to cite or link to this item:
|Title:||Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury|
|Keywords:||Bone marrow cells|
Traumatic brain injury
|Citation:||Lu, J., Moochhala, S., Ng, K.C., Tan, M.H., Lee, L.K.H., Moore, X.-L., Wong, M.C., He, B., Ling, E.-A. (2006). Adult bone marrow cells differentiate into neural phenotypes and improve functional recovery in rats following traumatic brain injury. Neuroscience Letters 398 (1-2) : 12-17. ScholarBank@NUS Repository. https://doi.org/10.1016/j.neulet.2005.12.053|
|Abstract:||This study aims to investigate the therapeutic potential of adult bone marrow stromal cells (BMSCs). Exposed to a cocktail of induction medium, some BMSCs could differentiate into cell types with phenotypes of neural lineages in vitro. These cells expressed neural markers nestin, GFAP, 68-kDa neurofilament and β-tubulin III as detected by immunohistochemistry and RT-PCR. Fluorescence-labeled cells were injected intravenously at 72 h after traumatic brain injury. Transplanted cells survived and migrated to the ipsilateral cerebral cortex at different time points after injection. They were immunopositive for neuronal marker MAP-2, oligodendrocyte marker CNPase, astrocytic maker GFAP or microglial marker OX-42 in vivo. In rats receiving BMSC transplants, there were significant improvements in motor and neurological functions when compared with the control groups. Hence, the therapeutic potential of BMSCs for traumatic brain injury is further amplified. © 2005 Elsevier Ireland Ltd. All rights reserved.|
|Source Title:||Neuroscience Letters|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Feb 15, 2019
WEB OF SCIENCETM
checked on Feb 6, 2019
checked on Jan 13, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.