Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.canlet.2005.07.002
Title: Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity
Authors: Pook, S.-H. 
Mahendran, R. 
Toh, C.-K.
Keywords: Antioxidants
Apoptosis
Bcl-2 proteins
Caspases
Chemotherapy
Issue Date: 2006
Source: Pook, S.-H., Mahendran, R., Toh, C.-K. (2006). Combination of thiol antioxidant Silibinin with Brostallicin is associated with increase in the anti-apoptotic protein Bcl-2 and decrease in caspase 3 activity. Cancer Letters 238 (1) : 146-152. ScholarBank@NUS Repository. https://doi.org/10.1016/j.canlet.2005.07.002
Abstract: The cytotoxic activity of Brostallicin was previously shown to be enhanced in the presence of high glutathione and glutathione transferase levels. We hypothesized that thiol antioxidants, N-acetylcysteine and Silibinin, could potentiate Brostallicin's cytotoxicity in a similar way. HepG2 and CNE-2 cells were treated with N-acetylcysteine, Silibinin and Brostallicin, either alone or in combination. Surprisingly, we found that NAC and Silibinin had adverse effects on Brostallicin's cytotoxicity. The mechanism underlying the interaction involved the apoptotic pathway as we demonstrated an increase in Bcl-2 protein levels and decrease in caspase 3 activity with the Silibinin-Brostallicin combination. © 2005 Elsevier Ireland Ltd. All rights reserved.
Source Title: Cancer Letters
URI: http://scholarbank.nus.edu.sg/handle/10635/24056
ISSN: 03043835
DOI: 10.1016/j.canlet.2005.07.002
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