Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/23173
Title: Supramolecular architectures formed by copolymers and cyclodextrins and their applications for gene delivery
Authors: YANG CHUAN
Keywords: Cyclodextrin, polyrotaxane, oligoethylenimine, inclusion complexation, polyethylenimine, non-viral gene delivery vectors
Issue Date: 22-Oct-2007
Source: YANG CHUAN (2007-10-22). Supramolecular architectures formed by copolymers and cyclodextrins and their applications for gene delivery. ScholarBank@NUS Repository.
Abstract: Cyclodextrins (CDs) are cyclic oligosaccharides, mainly consisting of 6, 7 or 8 I?-D-glucopyranose units (I?-CD, I?-CD and I?-CD) linked by I?-(1,4) bonds. These water-soluble, biocompatible oligosccharides do no elicit immune responses and have low toxicity in animals and humans. The objective of this thesis was to develop novel CD-based cationic polymers and supramolecular architectures for efficient gene delivery. In this study, a series of novel cationic star polymers consisting of i?!-CD core and oligoethylenimine (OEI) arms and cationic supramolecular polyrotaxanes composed of multiple OEI-grafted CDs threaded on various copolymer chains have been synthesized. Results indicated that these cationic polymers not only could efficiently compact plasmid DNA into small nanoparticles, but also showed excellent gene transfection efficiency and low in vitro cytotoxicity in various cell lines. Hence, they are promising non-viral gene delivery vectors and can be widely used in future gene therapy applications.
URI: http://scholarbank.nus.edu.sg/handle/10635/23173
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
YangC.pdf3.13 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

194
checked on Dec 18, 2017

Download(s)

447
checked on Dec 18, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.