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https://scholarbank.nus.edu.sg/handle/10635/23079
DC Field | Value | |
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dc.title | Identification and characterization of novel Group 5 and Group 21 allergens from dust mite and IgE binding epitope mapping of Blo t 5 | |
dc.contributor.author | GAO YUNFENG | |
dc.date.accessioned | 2011-06-10T18:01:39Z | |
dc.date.available | 2011-06-10T18:01:39Z | |
dc.date.issued | 2007-10-26 | |
dc.identifier.citation | GAO YUNFENG (2007-10-26). Identification and characterization of novel Group 5 and Group 21 allergens from dust mite and IgE binding epitope mapping of Blo t 5. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/23079 | |
dc.description.abstract | This thesis focuses on Group 5 and its homologues, the Group 21 allergens, aiming to achieve a comprehensive understanding of the mite allergy. The journey begins with the characterization of Blo t 21 allergen in B. tropicalis. Sensitization of Blo t 21 is strongly associated with allergic rhinitis. Allergic response to Blo t 21 is mainly induced by its specific epitopes. Eleven Group 5 and Group 21 allergens in seven species were identified and evaluated in local mite positive individuals (n=118), and results showed that they are able to induce allergic response. Blo t 5 was found to be the most important allergen among them. IgE-binding epitopes of Blo t 5 mapped by site-directed mutagenesis and systematic overlapping peptide mapping approaches revealed that multiple IgE-binding epitopes exist throughout Blo t 5. Different patients reacted to different epitopes and majority of patients responded to multiple epitopes of Blo t 5. | |
dc.language.iso | en | |
dc.subject | dust mite, allergen, Group 5, Group 21 | |
dc.type | Thesis | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.supervisor | CHEW FOOK TIM | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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Thesis-Gao Yunfeng.pdf | 2.57 MB | Adobe PDF | OPEN | None | View/Download |
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