Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/23079
Title: Identification and characterization of novel Group 5 and Group 21 allergens from dust mite and IgE binding epitope mapping of Blo t 5
Authors: GAO YUNFENG
Keywords: dust mite, allergen, Group 5, Group 21
Issue Date: 26-Oct-2007
Source: GAO YUNFENG (2007-10-26). Identification and characterization of novel Group 5 and Group 21 allergens from dust mite and IgE binding epitope mapping of Blo t 5. ScholarBank@NUS Repository.
Abstract: This thesis focuses on Group 5 and its homologues, the Group 21 allergens, aiming to achieve a comprehensive understanding of the mite allergy. The journey begins with the characterization of Blo t 21 allergen in B. tropicalis. Sensitization of Blo t 21 is strongly associated with allergic rhinitis. Allergic response to Blo t 21 is mainly induced by its specific epitopes. Eleven Group 5 and Group 21 allergens in seven species were identified and evaluated in local mite positive individuals (n=118), and results showed that they are able to induce allergic response. Blo t 5 was found to be the most important allergen among them. IgE-binding epitopes of Blo t 5 mapped by site-directed mutagenesis and systematic overlapping peptide mapping approaches revealed that multiple IgE-binding epitopes exist throughout Blo t 5. Different patients reacted to different epitopes and majority of patients responded to multiple epitopes of Blo t 5.
URI: http://scholarbank.nus.edu.sg/handle/10635/23079
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