Please use this identifier to cite or link to this item: http://scholarbank.nus.edu.sg/handle/10635/23075
Title: Helicobacter pylori: It's role in gastroesophageal reflux disease
Authors: HO YAN WING
Keywords: Helicobacter pylori, Virulence genes, Lewis antigens, Proinflammatory mechanism, Gastroesophageal reflux disease
Issue Date: 30-Mar-2007
Source: HO YAN WING (2007-03-30). Helicobacter pylori: It's role in gastroesophageal reflux disease. ScholarBank@NUS Repository.
Abstract: The role of Helicobacter pylori in Gastroesophageal reflux disease (GERD) is questioned when increase incidences of GERD coincided with the decline in H. pylori infection. Stomach (antrum, body and cardia) and oesophagus biopsies from 155 randomized GERD-symptomatic patients were examined for H. pylori. Of the 53 H. pylori-positive patients, 16 harboured the organism in oesophageal biopsies. Topological distribution and clinical outcomes of infection were independent of virulence genes expression and H. pylori-related carditis. Characterization of vacA alleles in isolates suggested the presence of multiple H. pylori strains. In addition, host and bacterial Lewis antigens were shown not to be involved in bacterial adhesion. H. pylori-infected non-neoplastic oesophageal cells (HET-1A) caused early apoptosis and activated proinflammatory cytokine pathways via p38 MAPK and NF-i?<B leading to IL8 production. This study indelibly demonstrates the ability of H. pylori in colonizing oesophageal cells both in-vivo and in-vitro, indicating its probable role in GERD pathogenesis.
URI: http://scholarbank.nus.edu.sg/handle/10635/23075
Appears in Collections:Ph.D Theses (Open)

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Title page.pdf10.44 kBAdobe PDF

OPEN

NoneView/Download
ACKNOWLEDGEMENTS.pdf10.34 kBAdobe PDF

OPEN

NoneView/Download
Table of Contents.pdf111.33 kBAdobe PDF

OPEN

NoneView/Download
Summary.pdf78.58 kBAdobe PDF

OPEN

NoneView/Download
LIST OF ABBREVIATIONS.pdf42.29 kBAdobe PDF

OPEN

NoneView/Download
LIST OF FIGURES.pdf34.21 kBAdobe PDF

OPEN

NoneView/Download
LIST OF TABLES.pdf17.71 kBAdobe PDF

OPEN

NoneView/Download
ListofPublications.pdf105.18 kBAdobe PDF

OPEN

NoneView/Download
Introduction.pdf34.76 kBAdobe PDF

OPEN

NoneView/Download
Literature Survey.pdf268.88 kBAdobe PDF

OPEN

NoneView/Download
Materials and Method.pdf321.36 kBAdobe PDF

OPEN

NoneView/Download
Results.pdf11.9 MBAdobe PDF

OPEN

NoneView/Download
Discussion.pdf244.71 kBAdobe PDF

OPEN

NoneView/Download
References.pdf331.23 kBAdobe PDF

OPEN

NoneView/Download
Appendix.pdf214.85 kBAdobe PDF

OPEN

NoneView/Download

Page view(s)

237
checked on Dec 18, 2017

Download(s)

1,862
checked on Dec 18, 2017

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.